Erythema Multiforme and Stevens-Johnson Syndrome (SJS, Erythema Multiforme Major) in Children — Symptoms and Treatment

Stevens-Johnson syndrome is an immune-complex mediated hypersensitivity reaction that can be triggered by infectious etiologies or the use of anticonvulsants, antibiotics or any other drug. The condition is characterized by epidermal necrolysis, separation of the epidermis from the dermis, and the formation of skin blisters and bullae over the face, lips, throat and upper or lower extremities. Patients usually have severe electrolyte disturbances due to excessive fluid loss. Management is largely supportive.